A Prospective Study to Correlate Cross-Sectional Computed Tomography Skeletal Muscle Loss with Functional Activity in Metastatic Cancer Patients on Chemotherapy
This project will discover and develop effective solutions to improve the quality of life of patients with cancer. One goal is to build symptom intervention evidence-based clinical practices and promote rigorous scientific validation of novel approaches. Another goal is to determine if cross-sectional CT body composition analysis can serve as a surrogate for functional activity. Objective 1: To determine if percent change in total lumbar muscle CT cross-sectional area at the third lumbar vertebra (L3) on CT correlates with percent change in functional activity on the Six Minute Walk Test at a single time point at 3 months from baseline. Objective 2: To determine if change in L3 cross-sectional muscle area on CT correlates with standard functional, anthropometric, and patient-reported outcomes assessments.